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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

protein tyrosine phosphatase 1B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphatase (43) PTEN (2) SHP2 (5) 5-HT Receptor (1) Aldose Reductase (1) Antibiotic (1) Apoptosis (3) Autophagy (1) Beta-secretase (1) Endogenous Metabolite (1) Glucosidase (2) Monoamine Oxidase (1) Parasite (3) Tie (1)
By Research Areas:	Cancer (9) Endocrinology (4) Infection (3) Inflammation/Immunology (5) Metabolic Disease (29) Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Phosphatase Btk Syk PTEN DYRK SHP2 Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12312

TCS 401

2 Publications Verification

Phosphatase Metabolic Disease

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

TCS 401 2 Publications Verification	Phosphatase	Metabolic Disease
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Phosphatase	Neurological Disease Metabolic Disease
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Phosphatase Apoptosis Autophagy	Inflammation/Immunology Cancer
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent **protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy** through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-135564B

(Rac)-RK-682	Phosphatase	Cancer
(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits **protein tyrosine phosphatase 1B (PTP-1B)*, low molecular weight protein* tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC₅₀s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively .

HY-N3267

Methyl pseudolarate B	Phosphatase	Metabolic Disease
Methyl pseudolarate B, a natural diterpenoid, is a **protein tyrosine phosphatase 1B (PTP1B)** (Phosphatase) inhibitor with an IC₅₀ value of 10.9 μM .

HY-N4185

Licoflavone A 1 Publications Verification	Phosphatase	Neurological Disease
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-100462

PTP1B-IN-2

3 Publications Verification

Phosphatase Metabolic Disease

PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

PTP1B-IN-2 3 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

HY-N10064

Ficusonolide	Others	Metabolic Disease
Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

HY-128978

(E,E)-RAMB4	Phosphatase	Metabolic Disease
(E,E)-RAMB4 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1 .

HY-19779

JTT 551
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

HY-N12736

Dehydrodanshenol A	Phosphatase	Metabolic Disease
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .

HY-N6650

Isotanshinone IIA	Phosphatase	Metabolic Disease
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-N0374

Licochalcone C 2 Publications Verification	Glucosidase	Metabolic Disease
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

HY-N10649

PTP1B-IN-21	Phosphatase	Metabolic Disease
PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC₅₀=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀>100 μM), which is a key target for type 2 diabetes inhibition .

HY-N10648

PTP1B-IN-20	Phosphatase	Metabolic Disease
PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC₅₀=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀=78.0 μM), which is a key target for type 2 diabetes inhibition .

HY-12219

MSI-1436 Trodusquemine; Aminosterol-1436	Phosphatase	Endocrinology
MSI-1436 is a selective, non-competitive inhibitor of the enzyme **protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀** of appr 1 μM, 200-fold preference over TCPTP (IC₅₀, 224 μM).

HY-12219A

MSI-1436 lactate 1 Publications Verification Trodusquemine lactate; Aminosterol-1436 lactate	Phosphatase	Endocrinology
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 1 μM, 200-fold preference over TCPTP (IC₅₀ of 224 μM).

HY-N1549

Prunin Naringenin 7-0-glucoside
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 5.5 µM .

HY-N4143

Cyanidin 3-arabinoside	Phosphatase	Metabolic Disease
Cyanidin 3-arabinoside is a selective and reversible **protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-10704

PTP1B-IN-1 5 Publications Verification PTP1B inhibitor	Phosphatase	Metabolic Disease
PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

HY-N2451

Aloe-emodin-8-O-β-D-glucopyranoside 1 Publications Verification	Phosphatase	Metabolic Disease Endocrinology
Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC₅₀ of 26.6 μM .

HY-108196

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .

HY-N1230

Sophoraisoflavone A Allolicoisoflavone B
Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent **protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀** value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B *(PTP1B)* and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

HY-144717

PTP1B-IN-18	Phosphatase	Metabolic Disease
PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research .

HY-N7599

Chrysophanol triglucoside	Phosphatase Glucosidase	Metabolic Disease
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits **protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC₅₀**s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

HY-144718

PTP1B-IN-17	Phosphatase	Metabolic Disease
PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.

HY-144716

PTP1B-IN-19	Phosphatase	Metabolic Disease
PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.

HY-144713

PTP1B-IN-16	Phosphatase	Metabolic Disease
PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.

HY-153018

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent **protein tyrosine phosphatase 1B (PTP1B)** inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes .

HY-N0646

Silydianin 1 Publications Verification	Phosphatase Endogenous Metabolite	Cancer
Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural **protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀** of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products .

HY-N3734

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Neurological Disease
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of **protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀** value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .

HY-123966

MY33-3	Phosphatase
MY33-3 is a potent and selective inhibitor of *receptor protein* tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC₅₀** ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction .

HY-123966A

MY33-3 hydrochloride	Phosphatase	Neurological Disease
MY33-3 hydrochloride is a potent and selective inhibitor of *receptor protein* tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC₅₀** ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction .

HY-120327

KY-226 1 Publications Verification	Phosphatase	Neurological Disease Metabolic Disease
KY-226 is a potent, selective, orally active and allosteric **protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀** of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .

HY-N1743

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes .

HY-136065

bpV(phen)	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and *PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania* in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

HY-122818

bpV(phen) trihydrate 2 Publications Verification	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and *PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania* in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

HY-149254

PTP1B/AKR1B1-IN-1	Phosphatase Aldose Reductase	Metabolic Disease
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC₅₀s of 0.06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC₅₀ value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels .

HY-N2111

Momordicoside A

Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on protein tyrosine phosphatase (PTP1B) .

Momordicoside A
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on **protein tyrosine phosphatase (PTP1B)** .

HY-15756

PTP1B-IN-4	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase *PTP1B, with an IC₅₀* of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .

HY-100595

Sodium stibogluconate 4 Publications Verification Stibogluconate trisodium nonahydrate	Phosphatase Parasite SHP2	Cancer
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of **protein tyrosine phosphatase**. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

HY-121515

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of **protein-tyrosine phosphatase (PTP1B) with an IC₅₀** of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

HY-121515A

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of **protein-tyrosine phosphatase (PTP1B) with an IC₅₀** of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property .

HY-101964

SPI-112	SHP2 Phosphatase	Cancer
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively .

HY-141800

MurA-IN-1 1 Publications Verification	Others	Others
MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC₅₀ values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively . (A family of human MAPK-specific protein tyrosine phosphatases)

HY-N12177

Cryptosporioptide A	Phosphatase	Metabolic Disease
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-120159

GS-493	SHP2 Phosphatase	Cancer
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC₅₀ of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity .

HY-118567

Bis(maltolato)oxovanadium(IV) BMOV	SHP2 Phosphatase	Metabolic Disease
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, *PTP1B, HPTPβ* and SHP2 with IC₅₀s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer .

HY-109041

Razuprotafib 1 Publications Verification AKB-9778	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

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protein tyrosine phosphatase 1B

Inhibitors & Agonists

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